Igf1r^tm2.1Arge
Targeted Allele Detail

Summary

• Symbol: Igf1r^tm2.1Arge
• Name: insulin-like growth factor I receptor; targeted mutation 2.1, Argiris Efstratiadis
• MGI ID: MGI:5306047
• Gene: Igf1r Location: Chr7:67602575-67883416 bp, + strand Genetic Position: Chr7, 37.27 cM
• Alliance: Igf1r^tm2.1Arge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178908
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was flanked by a floxed neo cassette in intron 2 and a single loxP site in intron 3. Subsequently, properly targeted mice were crossed to cre expressing mis leading to germ line excision of exon 3. (J:60711)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf1r Mutation: 88 strains or lines available

References

• Original: J:178908 Okano T, et al., Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea. J Neurosci. 2011 Dec 7;31(49):18104-18
• All: 3 reference(s)