Prdm9^M1045Lja
Chemically induced Allele Detail

Summary

• Symbol: Prdm9^M1045Lja
• Name: PR domain containing 9; mutation 1045, J Larry Jameson
• MGI ID: MGI:5306140
• Synonyms: 1045
• Gene: Prdm9 Location: Chr17:15763341-15784616 bp, - strand Genetic Position: Chr17, 8.95 cM
• Alliance: Prdm9^M1045Lja page

Incomplete dominance with spermatogenic block in Prdm9^M1045Lja/Prdm9⁺ mice or germ cell loss in Prdm9^M1045Lja/Prdm9^M1045Lja mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The original pupblication described this ENU induced mutation as an A739T mutation resulting in a leucine to stop mutation at position 247 (L247Stop). J:250814 found a different mutation, an A1276T mutation, with a stop codon at K426. A mutant truncated protein is expressed in germ cells, detected by an antibody that is presumably the N-terminal domains without the ZNF domain. (J:179895, J:250814)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdm9 Mutation: 46 strains or lines available

References

• Original: J:179895 Weiss J, et al., ENU mutagenesis in mice identifies candidate genes for hypogonadism. Mamm Genome. 2012 Jun;23(5-6):346-55
• All: 2 reference(s)