Col1a1^{tm8(CAG-BDNF)Jae}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm8(CAG-BDNF)Jae}
• Name: collagen, type I, alpha 1; targeted mutation 8, Rudolf Jaenisch
• MGI ID: MGI:5306239
• Synonyms: BDNF^stop
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm8(CAG-BDNF)Jae} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106973
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, RMCE-ready)
• Mutation: Insertion
• Col1a1^{tm8(CAG-BDNF)Jae} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BDNF (627)

  Bdnf	(MGI:88145)

• Mutation details: A transgenic construct consisting of a CAG promoter, a floxed stop cassette and an HA tagged human BDNF cDNA was inserted by flp mediated cassette exchange. (J:106973)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 163 strains or lines available

References

• Original: J:106973 Chang Q, et al., The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron. 2006 Feb 2;49(3):341-8
• All: 6 reference(s)