Tg(Igh-VSp6/IGHM)39Corc
Transgene Detail

Summary

• Symbol: Tg(Igh-VSp6/IGHM)39Corc
• Name: transgene insertion 39, Daniel Corcos
• MGI ID: MGI:5306240
• Synonyms: hmuSp6, hmuSp6-39
• Transgene: Tg(Igh-VSp6/IGHM)39Corc Location: unknown
• Alliance: Tg(Igh-VSp6/IGHM)39Corc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-VSp6/IGHM)39Corc expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  mouse

  Igh (MGI:96442)

  human

  IGHM (3507)

  Ighm	(MGI:96448)

• Mutation details: This chimeric transgene contains the rearranged immunoglobulin heavy chain (Igh) variable region [V(D)J] segments followed by the Igh enhancer from the mouse hybridoma Sp6 joined to a 9 kb fragment of human genomic sequence containing all of the IGHM (mu) constant region exons. This transgene encodes both secreted and membrane bound Cmu protein. Antibodies against human IgM demonstrate surface expression of the chimeric heavy chain on most B cells of transgenic mice. (J:133882)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:133882 Corcos D, et al., Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein. Curr Biol. 1995 Oct 1;5(10):1140-8
• All: 2 reference(s)