Slc6a12^tm1.1Ncd
Targeted Allele Detail

Summary

• Symbol: Slc6a12^tm1.1Ncd
• Name: solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12; targeted mutation 1.1, NC Danbolt
• MGI ID: MGI:5306247
• Synonyms: BGT1-flox
• Gene: Slc6a12 Location: Chr6:121320035-121342734 bp, + strand Genetic Position: Chr6, 57.25 cM, cytoband F1
• Alliance: Slc6a12^tm1.1Ncd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180428
• Parent Cell Line: D1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream to exon 3. A FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette and left exons 3 through 5 floxed. (J:180428)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc6a12 Mutation: 38 strains or lines available

References

• Original: J:180428 Lehre AC, et al., Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice. Epilepsy Res. 2011 Jun;95(1-2):70-81
• All: 2 reference(s)