Nr3c1^tm1.1Mvc
Targeted Allele Detail

Summary

• Symbol: Nr3c1^tm1.1Mvc
• Name: nuclear receptor subfamily 3, group C, member 1; targeted mutation 1.1, Moses V Chao
• MGI ID: MGI:5306342
• Synonyms: GR^flox
• Gene: Nr3c1 Location: Chr18:39543598-39652474 bp, - strand Genetic Position: Chr18, 21.09 cM
• Alliance: Nr3c1^tm1.1Mvc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179918
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exon 2 floxed. (J:179918)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr3c1 Mutation: 35 strains or lines available

References

• Original: J:179918 Jeanneteau FD, et al., BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1305-10
• All: 1 reference(s)