Slc24a4^tm1.1Hazh
Targeted Allele Detail

Summary

• Symbol: Slc24a4^tm1.1Hazh
• Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; targeted mutation 1.1, Haiqing Zhao
• MGI ID: MGI:5306364
• Synonyms: Nclx4^-
• Gene: Slc24a4 Location: Chr12:102094992-102233350 bp, + strand Genetic Position: Chr12, 51.42 cM
• Alliance: Slc24a4^tm1.1Hazh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180325
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 5 and the neo cassette. Immunohistochemistry confirmed the absence of protein expression in the olfactory bulb. (J:180325)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc24a4 Mutation: 34 strains or lines available

References

• Original: J:180325 Stephan AB, et al., The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response. Nat Neurosci. 2012 Jan;15(1):131-7
• All: 4 reference(s)