Mecom^tm2Miku
Targeted Allele Detail

Summary

• Symbol: Mecom^tm2Miku
• Name: MDS1 and EVI1 complex locus; targeted mutation 2, Mineo Kurokawa
• MGI ID: MGI:5306622
• Synonyms: Evi1^GFP
• Gene: Mecom Location: Chr3:30005445-30563937 bp, - strand Genetic Position: Chr3, 12.66 cM
• Alliance: Mecom^tm2Miku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178616
• Parent Cell Line: TT2F (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Reporter) Mutation: Insertion Mutation details: A murine cDNA encoding exons 10 through 15 of the gene followed by an IRES sequence, GFP, polyadenylation sequence, and neo cassette was inserted downstream of exon 9. (J:178616)

Generation of the knock-in Mecom^tm2Miku allele

Expression

In Mice Carrying this Mutation:

26 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecom Mutation: 81 strains or lines available

References

• Original: J:178616 Kataoka K, et al., Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity. J Exp Med. 2011 Nov 21;208(12):2403-16
• All: 5 reference(s)