Rhbdf1/Hba^{tm1(RHBDF1/HBA)Ajhs}
Targeted Allele Detail

Summary

• Symbol: Rhbdf1/Hba^{tm1(RHBDF1/HBA)Ajhs}
• Name: hemoglobin alpha chain complex; targeted mutation 1, Andrew JH Smith
• MGI ID: MGI:5306773
• Gene: Hba Location: unknown Genetic Position: Chr11, cytoband A

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117887
• Parent Cell Line: E14TG2aIV (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: RMCE using Hbq1a^tm1Ajhs and Rhbdf1^tm1Ajhs replaced the 87 kb intervening sequence with the corresponding human sequence. (J:117887)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hba Mutation: 10 strains or lines available

References

• Original: J:117887 Wallace HA, et al., Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence. Cell. 2007 Jan 12;128(1):197-209
• All: 1 reference(s)