Irf6^tm1.1Bcsl
Targeted Allele Detail

Summary

• Symbol: Irf6^tm1.1Bcsl
• Name: interferon regulatory factor 6; targeted mutation 1.1, Brian C Schuttes
• MGI ID: MGI:5306935
• Synonyms: Irf6^del, Irf6^nl
• Gene: Irf6 Location: Chr1:192835419-192854331 bp, + strand Genetic Position: Chr1, 97.6 cM
• Alliance: Irf6^tm1.1Bcsl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180634
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted in introns 2 and 4. Subsequent cre excision deleted exons 3 and 4 which contain critical sequences of the DNA binding domain and causes a frameshift mutation. (J:180634, J:242906)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irf6 Mutation: 26 strains or lines available

References

• Original: J:180634 Biggs LC, et al., Interferon regulatory factor 6 is necessary, but not sufficient, for keratinocyte differentiation. J Invest Dermatol. 2012 Jan;132(1):50-8
• All: 5 reference(s)