Grin2c^tm2(icre)Mwa
Targeted Allele Detail

Summary

• Symbol: Grin2c^tm2(icre)Mwa
• Name: glutamate receptor, ionotropic, NMDA2C (epsilon 3); targeted mutation 2, Masahiko Watanabe
• MGI ID: MGI:5306941
• Synonyms: E3CreN, GluN2C^iCre
• Gene: Grin2c Location: Chr11:115139995-115158069 bp, - strand Genetic Position: Chr11, 80.8 cM
• Alliance: Grin2c^tm2(icre)Mwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180582
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Grin2c^tm2(icre)Mwa expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Grin2c (MGI:95822)

• Mutation details: A vector was constructed to insert an improved cre recombinase and an Frt-flanked neomycin cassette into the translation initiation site (in-frame) of the Grin2c gene by homologous recombination in RENKA ES cells. (J:180582)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Grin2c (mouse) Summary of all recombinase alleles driven by Grin2c. Alliance mouse Grin2c gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin2c Mutation: 56 strains or lines available

References

• Original: J:180582 Miyazaki T, et al., Cav2.1 in Cerebellar Purkinje Cells Regulates Competitive Excitatory Synaptic Wiring, Cell Survival, and Cerebellar Biochemical Compartmentalization. J Neurosci. 2012 Jan 25;32(4):1311-1328
• All: 9 reference(s)