Slc4a5^tm1.1Boet
Targeted Allele Detail

Summary

• Symbol: Slc4a5^tm1.1Boet
• Name: solute carrier family 4, sodium bicarbonate cotransporter, member 5; targeted mutation 1, Thomas Boettger
• MGI ID: MGI:5306980
• Synonyms: Slc4a5^delta7
• Gene: Slc4a5 Location: Chr6:83196810-83281927 bp, + strand Genetic Position: Chr6, 35.94 cM
• Alliance: Slc4a5^tm1.1Boet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180608
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed the neo cassette. A quantitative mass-spectroscopy-based proteomic approach (SILAC-MS) confirmed the absence of protein expression. (J:180608)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc4a5 Mutation: 51 strains or lines available

References

• Original: J:180608 Groger N, et al., Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis. Hum Mol Genet. 2012 Mar 1;21(5):1025-36
• All: 2 reference(s)