Tg(H2-D^b)2Bujf
Transgene Detail

Summary

• Symbol: Tg(H2-D^b)2Bujf
• Name: transgene insertion 2, Jean-Francois Bureau
• MGI ID: MGI:5306998
• Synonyms: H2-Db2
• Transgene: Tg(H2-D^b)2Bujf Location: unknown
• Alliance: Tg(H2-D^b)2Bujf page

Transgene origin

• Strain of Origin: FVB/NPas

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-D^b)2Bujf expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	H2-D (MGI:1933561)

• Mutation details: The transgene comprises a 10-kb HindIII restriction fragment of genomic DNA from the C57BL/6 (haplotype H2^b) mouse strain containing the entire, eight-exon major histocompatibility (MHC) class I H2-D gene, more than 4 kb of 5' flanking DNA including the promoter and all known regulatory sequences, and approximately 1 kb of 3' flanking DNA. Activated peripheral blood lymphocytes of transgenic mice stain with a monoclonal antibody specific for H-2D^b and H2-K^b proteins. (FVB is of the H2^q haplotype.) (J:18556)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

One female (Founder I) and one male (Founder II) transgenic founders were recovered. Mouse lines derived from both exhibit the same phenotype.

References

• Original: J:18556 Azoulay A, et al., FVB mice transgenic for the H-2Db gene become resistant to persistent infection by Theiler's virus. J Virol. 1994 Jun;68(6):4049-52
• All: 1 reference(s)