Card11^tm1.1Litt
Targeted Allele Detail

Summary

• Symbol: Card11^tm1.1Litt
• Name: caspase recruitment domain family, member 11; targeted mutation 1.1, Dan R Littman
• MGI ID: MGI:5307006
• Synonyms: Carma1^F
• Gene: Card11 Location: Chr5:140858745-140986337 bp, - strand Genetic Position: Chr5, 79.42 cM
• Alliance: Card11^tm1.1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180410
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted into intron 2 and a loxP-flanked neomycin selection cassette was inserted into intron 4 through homologous recombination. Subsequent cre excision removed the floxed neomycin selection cassette. (J:89322)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Card11 Mutation: 59 strains or lines available

References

• Original: J:180410 Ramadas RA, et al., CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma. J Immunol. 2011 Dec 15;187(12):6197-207
• All: 2 reference(s)