Mir124a-1hg^tm1Tfur
Targeted Allele Detail

Summary

• Symbol: Mir124a-1hg^tm1Tfur
• Name: Mir124-1 host gene (non-protein coding); targeted mutation 1, Takahisa Furukawa
• MGI ID: MGI:5307015
• Synonyms: Rncr3^-
• Gene: Mir124a-1hg Location: Chr14:64825564-64831410 bp, + strand Genetic Position: Chr14, 33.77 cM
• Alliance: Mir124a-1hg^tm1Tfur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179784
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequence was replaced with a neo cassette. Northern blot analysis confirmed a 60-80% reduction in Mir124a (primarily Mir124a-1). (J:179784)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mir124a-1hg Mutation: 3 strains or lines available

References

• Original: J:179784 Sanuki R, et al., miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression. Nat Neurosci. 2011 Sep;14(9):1125-34
• All: 3 reference(s)