A930011O12Rik/Mir124a-1^tm1Tfur
Targeted Allele Detail

Summary

• Symbol: A930011O12Rik/Mir124a-1^tm1Tfur
• Name: microRNA 124a-1; targeted mutation 1, Takahisa Furukawa
• MGI ID: MGI:5307017
• Synonyms: Rncr3^-
• Gene: Mir124a-1 Location: Chr14:64828106-64828190 bp, + strand Genetic Position: Chr14, 33.77 cM
• Alliance: A930011O12Rik/Mir124a-1^tm1Tfur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179784
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All exons of A930011012Rik were replaced with a neo cassette. Northern blot analysis confirmed a 60-80% reduction in Mir124a (primarily Mir124a-1). (J:179784)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir124a-1 Mutation: 1 strain or line available

References

• Original: J:179784 Sanuki R, et al., miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression. Nat Neurosci. 2011 Sep;14(9):1125-34
• All: 2 reference(s)