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Grin2btm1.1(Grin2a)Bjha
Targeted Allele Detail
Summary
Symbol: Grin2btm1.1(Grin2a)Bjha
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2); targeted mutation 1.1, Benjamin J Hall
MGI ID: MGI:5307054
Synonyms: 2B->2A
Gene: Grin2b  Location: Chr6:135690231-136150509 bp, - strand  Genetic Position: Chr6, 66.38 cM
Alliance: Grin2btm1.1(Grin2a)Bjha page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178913
Parent Cell Line:  MC1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4, the first coding exon, was replaced with the a cDNA encoding for rat Grin2a and a loxP site flanked neomycin resistance gene cassette via homologous recombination. Cre mediated recombination removed the neo cassette. Western blot analysis indicates premature expression of Grin2a and absence of expression of Grin2b in homozygous mice. (J:178913)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grin2b Mutation:  99 strains or lines available
References
Original:  J:178913 Wang CC, et al., A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function. Neuron. 2011 Dec 8;72(5):789-805
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory