Cacng8^tm1.1Suto
Targeted Allele Detail

Summary

• Symbol: Cacng8^tm1.1Suto
• Name: calcium channel, voltage-dependent, gamma subunit 8; targeted mutation 1.1, Susumu Tomita
• MGI ID: MGI:5307062
• Synonyms: gamma-8^delta4
• Gene: Cacng8 Location: Chr7:3442558-3464782 bp, + strand Genetic Position: Chr7, 1.98 cM
• Alliance: Cacng8^tm1.1Suto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179775
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequence encoding the last four amino acids, the PDZ ligand, was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. (J:179775)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacng8 Mutation: 31 strains or lines available

References

• Original: J:179775 Sumioka A, et al., PDZ binding of TARPgamma-8 controls synaptic transmission but not synaptic plasticity. Nat Neurosci. 2011 Nov;14(11):1410-2
• All: 1 reference(s)