Trip12^tm1Jyan
Targeted Allele Detail

Summary

• Symbol: Trip12^tm1Jyan
• Name: thyroid hormone receptor interactor 12; targeted mutation 1, Junn Yanagisawa
• MGI ID: MGI:5307150
• Synonyms: mt #1, Trip12^mt
• Gene: Trip12 Location: Chr1:84698910-84818237 bp, - strand Genetic Position: Chr1, 43.42 cM, cytoband F
• Alliance: Trip12^tm1Jyan page

Delayed development in E8.5 Trip12^tm1Jyan/Trip12^tm1Jyan embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179766
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: FLAG and HA epitope tags were fused to exon 32 and exon 33 was replaced with a neo cassette. The predicted protein lacks the catalytic core of the HECT domain. (J:179766)

Generation of the Trip12^tm1Jyan allele

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trip12 Mutation: 167 strains or lines available

References

• Original: J:179766 Kajiro M, et al., The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis. PLoS One. 2011;6(10):e25871
• All: 1 reference(s)