Uqcrfs1^tm1.1Hek
Targeted Allele Detail

Summary

• Symbol: Uqcrfs1^tm1.1Hek
• Name: ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; targeted mutation 1.1, Siegfried Hekimi
• MGI ID: MGI:5307154
• Synonyms: Risp^P224S
• Gene: Uqcrfs1 Location: Chr13:30724295-30729299 bp, - strand Genetic Position: Chr13, 13.23 cM, cytoband A3.3
• Alliance: Uqcrfs1^tm1.1Hek page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179765
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions (CCC to TCG) result in the amino acid substitution of serine for proline at position 224 (P224S). This mutation is equivalent to one found in long-lived isp-1 (qm150) worms. Flp-mediated recombination removed the neo cassette used for selection purposes. (J:179765)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Uqcrfs1 Mutation: 19 strains or lines available

References

• Original: J:179765 Hughes BG, et al., A mild impairment of mitochondrial electron transport has sex-specific effects on lifespan and aging in mice. PLoS One. 2011;6(10):e26116
• All: 2 reference(s)