Tac2^{tm1.1(cre)Qima}
Targeted Allele Detail

Summary

• Symbol: Tac2^{tm1.1(cre)Qima}
• Name: tachykinin 2; targeted mutation 1.1, Qiufu Ma
• MGI ID: MGI:5307922
• Synonyms: Tac2-Cre
• Gene: Tac2 Location: Chr10:127560347-127567637 bp, + strand Genetic Position: Chr10, 74.81 cM, cytoband D3
• Alliance: Tac2^{tm1.1(cre)Qima} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180805
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Tac2^{tm1.1(cre)Qima} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tac2 (MGI:98476)

• Mutation details: The cre coding sequence with a poly adenylation signal was inserted in-frame with the first ATG of the Tac2 gene by homologous recombination. The initial targeting vector contained an Frt-flanked neomycin cassette. Germline-transmitting mice were crossed with a Flp deleter strain to excise the neo cassette. Insertion of the cre cassette results in generation of a null allele of Tac2 demonstrated by absence of Tac2 expression in the dorsal spinal cord as detected by in situ hybridization. (J:180805)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tac2 (mouse) Summary of all recombinase alleles driven by Tac2. Alliance mouse Tac2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tac2 Mutation: 18 strains or lines available

References

• Original: J:180805 Mar L, et al., Genetic marking and characterization of Tac2-expressing neurons in the central and peripheral nervous system. Mol Brain. 2012;5:3
• All: 9 reference(s)