Cd207^{tm2.1(cre)Bjec}
Targeted Allele Detail

Summary

• Symbol: Cd207^{tm2.1(cre)Bjec}
• Name: CD207 antigen; targeted mutation 2.1, Bjorn Clausen
• MGI ID: MGI:5308064
• Synonyms: Langerin-Cre
• Gene: Cd207 Location: Chr6:83648197-83654839 bp, - strand Genetic Position: Chr6, 35.94 cM, cytoband D1-D2
• Alliance: Cd207^{tm2.1(cre)Bjec} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179630
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Cd207^{tm2.1(cre)Bjec} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cd207 (MGI:2180021)

• Mutation details: A cDNA encoding cre recombinase with a bovine polyadenylation sequence and a nuclear localization signal (NLS) and followed by an Frt-flanked neo cassette was inserted into exon 2 of Cd207 (langerin) by homologous recombination. After verifying germline transmission, the neo resistance cassette was deleted from the allele by breeding founders to FLPe-expressing mice. (J:179630)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cd207 (mouse) Summary of all recombinase alleles driven by Cd207. Alliance mouse Cd207 gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd207 Mutation: 25 strains or lines available

References

• Original: J:179630 Zahner SP, et al., Conditional deletion of TGF-betaR1 using Langerin-Cre mice results in Langerhans cell deficiency and reduced contact hypersensitivity. J Immunol. 2011 Nov 15;187(10):5069-76
• All: 16 reference(s)