Mavs^tm1Camb
Targeted Allele Detail

Summary

• Symbol: Mavs^tm1Camb
• Name: mitochondrial antiviral signaling protein; targeted mutation 1, John C Cambier
• MGI ID: MGI:5308082
• Synonyms: VISA^-
• Gene: Mavs Location: Chr2:131075983-131089945 bp, + strand Genetic Position: Chr2, 63.3 cM
• Alliance: Mavs^tm1Camb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180356
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced the sequence between the translation initiation site in exon 2 through part of exon 5. Western blot analysis confirmed the absence of protein expression in splenic cells. (J:180356)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mavs Mutation: 36 strains or lines available

References

• Original: J:180356 Xu LG, et al., VISA is required for B cell expression of TLR7. J Immunol. 2012 Jan 1;188(1):248-58
• All: 3 reference(s)