Lbr^lym3
Chemically induced Allele Detail

Summary

• Symbol: Lbr^lym3
• Name: lamin B receptor; lymphocyte affected 3
• MGI ID: MGI:5308091
• Gene: Lbr Location: Chr1:181642880-181669933 bp, - strand Genetic Position: Chr1, 84.89 cM
• Alliance: Lbr^lym3 page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a C to A nucleotide substitution in exon 10 that results in the amino acid substitution of alanine for glutamic acid at position 418 (E418A). (J:180355)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lbr Mutation: 57 strains or lines available

Notes

Originally isolated from Mpl^tm1Wsa mice treated with ENU.

References

• Original: J:180355 Verhagen AM, et al., Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia. J Immunol. 2012 Jan 1;188(1):122-34
• All: 1 reference(s)