Siglech^tm1.1Ksat
Targeted Allele Detail

Summary

• Symbol: Siglech^tm1.1Ksat
• Name: sialic acid binding Ig-like lectin H; targeted mutation 1.1, Katsuaki Sato
• MGI ID: MGI:5308226
• Synonyms: Siglech^dtr
• Gene: Siglech Location: Chr7:55417926-55428673 bp, + strand Genetic Position: Chr7, 33.42 cM
• Alliance: Siglech^tm1.1Ksat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179283
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A fusion of human DTR and EGFP, an IRES sequence, and a self excising Cre-Neo cassette were inserted in the 3' untranslated region via homologous recombination. Plasmacytoid dendritic cells from homozygous mice are deficient in transcriptional and cell surface expression. (J:179283)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Siglech Mutation: 24 strains or lines available

References

• Original: J:179283 Takagi H, et al., Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo. Immunity. 2011 Dec 23;35(6):958-71
• All: 8 reference(s)