Ncr1^{tm1.1(icre)Viv}
Targeted Allele Detail

Summary

• Symbol: Ncr1^{tm1.1(icre)Viv}
• Name: natural cytotoxicity triggering receptor 1; targeted mutation 1.1, Eric Vivier
• MGI ID: MGI:5308410
• Synonyms: Cd335Cre, NKp46-cre, Nkp46^iCre, NKp46-iCre
• Gene: Ncr1 Location: Chr7:4340723-4348163 bp, + strand Genetic Position: Chr7, 2.5 cM
• Alliance: Ncr1^{tm1.1(icre)Viv} page

Generation of Ncr1^{tm1.1(icre)Viv}.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180265
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Ncr1^{tm1.1(icre)Viv} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ncr1 (MGI:1336212)

• Mutation details: An IRES-icre-Frt-neo-Frt cassette was inserted at the 3' end of the Ncr1 (Nkp46) gene by homologous recombination. The resulting mice were crossed to an Flp expressing strain to excise the neo resistance cassette. (J:180265)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ncr1 (mouse) Summary of all recombinase alleles driven by Ncr1. Comparative matrix view of recombinase activities Alliance mouse Ncr1 gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ncr1 Mutation: 40 strains or lines available

References

• Original: J:180265 Narni-Mancinelli E, et al., Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18324-9
• All: 119 reference(s)