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Cfap126tm1.1(icre)Heli
Targeted Allele Detail
Summary
Symbol: Cfap126tm1.1(icre)Heli
Name: cilia and flagella associated protein 126; targeted mutation 1.1, Heiko Lickert
MGI ID: MGI:5308442
Synonyms: 1700009P17Riktm1.1(icre)Heli, FltpT2AiCre
Gene: Cfap126  Location: Chr1:170941487-170954536 bp, + strand  Genetic Position: Chr1, 78.96 cM
Alliance: Cfap126tm1.1(icre)Heli page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180887
Parent Cell Line:  IDG3.2 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Cfap126tm1.1(icre)Heli expression driven by 1 gene
 
Mutation detailsA vector was constructed to insert a strept/FLAG-tandem affinity tag (SF-TAG) followed by a T2A peptide sequence (from Thosea asigna virus) and the codon-improved cre recombinase (icre) sequence into exon 6 of the 1700009P17Rik gene (called Flattop; Fltp). An Frt-flanked PGK-neo sequence followed cre in the construct. The targeting vector was introduced into IDG3.2 ES cells for homologous recombination. Southern blotting showed that recombination occurred on the C57BL/6J allele. After germline transmission was established, mice were crossed to Flpe-expressing line to remove the neo cassette. (J:180887)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cfap126 (mouse)
Summary of all recombinase alleles driven by Cfap126.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cfap126 Mutation:  15 strains or lines available
References
Original:  J:180887 Lange A, et al., Fltp(T2AiCre): A new knock-in mouse line for conditional gene targeting in distinct mono- and multiciliated tissues. Differentiation. 2012 Feb;83(2):S105-13
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory