Slco1c1^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Slco1c1^tm1.1Arte
• Name: solute carrier organic anion transporter family, member 1c1; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5308446
• Synonyms: Oatp1c1 delta
• Gene: Slco1c1 Location: Chr6:141470094-141515903 bp, + strand Genetic Position: Chr6, 72.38 cM, cytoband G1
• Alliance: Slco1c1^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180950
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was flanked with loxP sites. Deletion of exon 3 by cre excision caused loss of function by removing part of the organic anion transporter domain and generating a frameshift from exon 2 to exon 4-11 followed by a premature stop at codon 52. PCR analysis confirmed the removal of exon 3 in mRNA. (J:180950)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slco1c1 Mutation: 33 strains or lines available

References

• Original: J:180950 Mayerl S, et al., Impact of oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain. Endocrinology. 2012 Mar;153(3):1528-37
• All: 10 reference(s)