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Slco1c1tm1.1Arte
Targeted Allele Detail
Summary
Symbol: Slco1c1tm1.1Arte
Name: solute carrier organic anion transporter family, member 1c1; targeted mutation 1.1, TaconicArtemis
MGI ID: MGI:5308446
Synonyms: Oatp1c1 delta
Gene: Slco1c1  Location: Chr6:141470094-141515903 bp, + strand  Genetic Position: Chr6, 72.38 cM, cytoband G1
Alliance: Slco1c1tm1.1Arte page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180950
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was flanked with loxP sites. Deletion of exon 3 by cre excision caused loss of function by removing part of the organic anion transporter domain and generating a frameshift from exon 2 to exon 4-11 followed by a premature stop at codon 52. PCR analysis confirmed the removal of exon 3 in mRNA. (J:180950)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slco1c1 Mutation:  33 strains or lines available
References
Original:  J:180950 Mayerl S, et al., Impact of oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain. Endocrinology. 2012 Mar;153(3):1528-37
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory