Chrna4^tm1.1Stit
Targeted Allele Detail

Summary

• Symbol: Chrna4^tm1.1Stit
• Name: cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 1.1, Jerry A Stitzel
• MGI ID: MGI:5308461
• Synonyms: Chrna4 T529A
• Gene: Chrna4 Location: Chr2:180664104-180685339 bp, - strand Genetic Position: Chr2, 103.54 cM
• Alliance: Chrna4^tm1.1Stit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180872
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A point mutation results in the amino acid substitution of alanine for threonine at position 529 (T529A). Cre-mediated recombination removed an intronic neo selection cassette. (J:180872)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrna4 Mutation: 44 strains or lines available

References

• Original: J:180872 Wilking JA, et al., Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity. Pharmacogenet Genomics. 2010 Feb;20(2):121-30
• All: 1 reference(s)