Lair1^tm1Jco
Targeted Allele Detail

Summary

• Symbol: Lair1^tm1Jco
• Name: leukocyte-associated Ig-like receptor 1; targeted mutation 1, John E Coligan
• MGI ID: MGI:5308462
• Synonyms: LAIR-1^fl/fl
• Gene: Lair1 Location: Chr7:4006401-4066178 bp, - strand Genetic Position: Chr7, 2.31 cM
• Alliance: Lair1^tm1Jco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180203
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 4 followed by a frt-flanked neomycin resistance (neo) cassette and a second loxP site downstream of exon 8 via homologous recombination. Exons 4-8 contain two immunoreceptor tyrosine-based inhibition motifs (ITIM)that interact with the tyrosine phosphatases SHP1, SHP2 and SRC kinase. (J:180203)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lair1 Mutation: 37 strains or lines available

References

• Original: J:180203 Tang X, et al., Leukocyte-associated Ig-like receptor-1-deficient mice have an altered immune cell phenotype. J Immunol. 2012 Jan 15;188(2):548-58
• All: 1 reference(s)