Lair1^tm1.1Jco
Targeted Allele Detail

Summary

• Symbol: Lair1^tm1.1Jco
• Name: leukocyte-associated Ig-like receptor 1; targeted mutation 1.1, John E Coligan
• MGI ID: MGI:5308465
• Gene: Lair1 Location: Chr7:4006401-4066178 bp, - strand Genetic Position: Chr7, 2.31 cM
• Alliance: Lair1^tm1.1Jco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180203
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 followed by a frt-flanked neomycin resistance (neo) cassette and a second loxP site inserted downstream of exon 8 via homologous recombination. Cre-mediated recombination removed exons 4-8 and the neo cassette. Flow cytometric analysis confirmed that LAIR1 could not be detected on T, B, and NK cells derived from splenocytes. (J:180203)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lair1 Mutation: 37 strains or lines available

References

• Original: J:180203 Tang X, et al., Leukocyte-associated Ig-like receptor-1-deficient mice have an altered immune cell phenotype. J Immunol. 2012 Jan 15;188(2):548-58
• All: 6 reference(s)