Dnase1l2^tm1Eckh
Targeted Allele Detail

Summary

• Symbol: Dnase1l2^tm1Eckh
• Name: deoxyribonuclease 1-like 2; targeted mutation 1, Leopold Eckhart
• MGI ID: MGI:5308556
• Gene: Dnase1l2 Location: Chr17:24659054-24662075 bp, - strand Genetic Position: Chr17, 12.39 cM, cytoband A3.3
• Alliance: Dnase1l2^tm1Eckh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180935
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 2-6 were replaced by a neomycin resistance cassette. (J:180935)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnase1l2 Mutation: 26 strains or lines available

References

• Original: J:180935 Fischer H, et al., Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails. J Invest Dermatol. 2011 Jun;131(6):1208-15
• All: 4 reference(s)