Pax7^{tm1.1(HBEGF,-EYFP)Mal}
Targeted Allele Detail

Summary

• Symbol: Pax7^{tm1.1(HBEGF,-EYFP)Mal}
• Name: paired box 7; targeted mutation 1.1, Bernard Malissen
• MGI ID: MGI:5308728
• Synonyms: Pax7^DTR, Pax7^{tm1.1(HBEGF)Mal}, Pax7^tm1Mal
• Gene: Pax7 Location: Chr4:139464373-139560839 bp, - strand Genetic Position: Chr4, 70.83 cM
• Alliance: Pax7^{tm1.1(HBEGF,-EYFP)Mal} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180899
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout, Reporter)
• Mutation: Insertion
• Pax7^{tm1.1(HBEGF,-EYFP)Mal} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: Sequence for the human diphtheria toxin receptor (HBEGF) cDNA, an IRES, the EYFP fluorescent reporter gene, a loxP site, the mouse Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) promoter, the cre recombinase gene, a neomycin resistance gene cassette, and a second loxP site, was inserted after the ATG translation start site, abolishing endogenous translation of the host gene in the allele. Cre-mediated recombination in the male germline removed the cre+neo cassette. No YFP expression was detected. (J:180899)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax7 Mutation: 38 strains or lines available

References

• Original: J:180899 Sambasivan R, et al., Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration. Development. 2011 Sep;138(17):3647-56
• All: 3 reference(s)