Mir34a^tm1.1Lhe
Targeted Allele Detail

Summary

• Symbol: Mir34a^tm1.1Lhe
• Name: microRNA 34a; targeted mutation 1.1, Lin He
• MGI ID: MGI:5308792
• Synonyms: Mir34a^tm1.1Ghan
• Gene: Mir34a Location: Chr4:150152911-150153012 bp, + strand Genetic Position: Chr4, 80.85 cM
• Alliance: Mir34a^tm1.1Lhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180692
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: The microRNA was replaced with a lacZ gene and neo cassette flanked by neo and FRT sites. Flp-mediated recombination removed the neo cassette. Real-time PCR confirmed the absence of transcript expression in mouse embryonic fibroblasts. (J:180692)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir34a Mutation: 9 strains or lines available

References

• Original: J:180692 Choi YJ, et al., miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 2011 Nov;13(11):1353-60
• All: 6 reference(s)