Bst2^tm1.1Bsz
Targeted Allele Detail

Summary

• Symbol: Bst2^tm1.1Bsz
• Name: bone marrow stromal cell antigen 2; targeted mutation 1.1, Paul Bieniasz
• MGI ID: MGI:5308812
• Gene: Bst2 Location: Chr8:71986899-71990100 bp, - strand Genetic Position: Chr8, 34.43 cM
• Alliance: Bst2^tm1.1Bsz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180252
• Parent Cell Line: CY2.4 (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted into exon 1. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed most of exon 1. RT-PCR confirmed the absence of transcript expression in mouse embryonic fibroblasts. (J:180252)

Generation of the Bst2^tm1Bsz and Bst2^tm1.1Bsz alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bst2 Mutation: 12 strains or lines available

References

• Original: J:180252 Liberatore RA, et al., Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivo. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18097-101
• All: 8 reference(s)