Synb^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Synb^tm1.2Ics
• Name: syncytin b; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:5308859
• Gene: Synb Location: Chr14:69526793-69531748 bp, - strand Genetic Position: Chr14, 36.04 cM
• Alliance: Synb^tm1.2Ics page

Placental anomalies in the labyrinth of Synb^tm1.2Ics/Synb^tm1.2Ics embryos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180242
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination removed the coding sequence from Synb^tm1.1Ics. (J:180242)

Targeted disruption of the single exon Synb gene to generate the Synb^tm1.1Ics and Synb^tm1.2Ics alleles

Expression

In Mice Carrying this Mutation:	6 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Synb Mutation: 7 strains or lines available

References

• Original: J:180242 Dupressoir A, et al., A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1164-73
• All: 3 reference(s)