Tg(Ins2-crmA)27Ngkh
Transgene Detail

Summary

• Symbol: Tg(Ins2-crmA)27Ngkh
• Name: transgene insertion 27, Nicolas Glaichenhaus
• MGI ID: MGI:5308875
• Synonyms: RIP-CrmA, RIP-CrmA-27
• Transgene: Tg(Ins2-crmA)27Ngkh Location: unknown
• Alliance: Tg(Ins2-crmA)27Ngkh page

Transgene origin

• Strain of Origin: NOD

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains cDNA encoding cowpox cytokine response modifier A (CrmA), which blocks receptor mediated apoptosis by inhibiting caspase activity, under control of the rat insulin II promoter to direct its expression in pancreatic beta cells. (J:132052)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This is one of three transgenic lines, which the authors designate RIP-CrmA-27, -51 and -79, that were generated and characterized on the NOD background. (J:132052)

References

• Original: J:132052 Hugues S, et al., Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells. Immunity. 2002 Feb;16(2):169-81
• All: 1 reference(s)