Ctnnb1^tm1Kba
Targeted Allele Detail

Summary

• Symbol: Ctnnb1^tm1Kba
• Name: catenin beta 1; targeted mutation 1, Konrad Basler
• MGI ID: MGI:5308943
• Synonyms: Beta-catenin^D164A
• Gene: Ctnnb1 Location: Chr9:120762466-120789573 bp, + strand Genetic Position: Chr9, 72.19 cM
• Alliance: Ctnnb1^tm1Kba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178971
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A point mutation was introduced into exon 4 resulting in a D164A mutation and a floxed hygromycin cassette was inserted via homologous recombination. Homozygous mice show a strong reduction in Wnt/Beta catenin activity at E10. (J:178971)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnnb1 Mutation: 49 strains or lines available

References

• Original: J:178971 Valenta T, et al., Probing transcription-specific outputs of beta-catenin in vivo. Genes Dev. 2011 Dec 15;25(24):2631-43
• All: 4 reference(s)