Asl^tm1Brle
Targeted Allele Detail

Summary

• Symbol: Asl^tm1Brle
• Name: argininosuccinate lyase; targeted mutation 1, Brendan Lee
• MGI ID: MGI:5308970
• Synonyms: Asl^Neo
• Gene: Asl Location: Chr5:130040099-130053222 bp, - strand Genetic Position: Chr5, 68.37 cM
• Alliance: Asl^tm1Brle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180208
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site was inserted downstream of exon 7. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 9. Western blot analysis confirmed a reduction in protein expression. This allele is hypomorphic. (J:180208)

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Asl Mutation: 26 strains or lines available

References

• Original: J:180208 Erez A, et al., Requirement of argininosuccinate lyase for systemic nitric oxide production. Nat Med. 2011 Dec;17(12):1619-26
• All: 11 reference(s)