Cd8a^{tm2.1(Cd4)Asin}
Targeted Allele Detail

Summary

• Symbol: Cd8a^{tm2.1(Cd4)Asin}
• Name: CD8 subunit alpha; targeted mutation 2.1, Alfred Singer
• MGI ID: MGI:5309010
• Synonyms: 4in8, Cd8a^CD4
• Gene: Cd8a Location: Chr6:71350411-71356155 bp, + strand Genetic Position: Chr6, 32.14 cM, cytoband C
• Alliance: Cd8a^{tm2.1(Cd4)Asin} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180236
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-4 were replaced with a Cd4 cDNA and a floxed neomycin selection cassette. The selection cassette was subsequently removed by cre excision. (J:180236)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd8a Mutation: 39 strains or lines available

References

• Original: J:180236 Adoro S, et al., Coreceptor gene imprinting governs thymocyte lineage fate. EMBO J. 2011;31(2):366-77
• All: 2 reference(s)