Ncr1^noe
Chemically induced Allele Detail

Summary

• Symbol: Ncr1^noe
• Name: natural cytotoxicity triggering receptor 1; noe
• MGI ID: MGI:5309015
• Synonyms: NKp46^W32R
• Gene: Ncr1 Location: Chr7:4340723-4348163 bp, + strand Genetic Position: Chr7, 2.5 cM
• Alliance: Ncr1^noe page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU induced a point mutation that results in the replacement of the tryptophan 32 residue with an arginine residue. Transcript expression in natural killer cells from homozygous mice is similar to wild-type mice but the protein is not detected on the cell surface. (J:179728)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncr1 Mutation: 40 strains or lines available

References

• Original: J:179728 Narni-Mancinelli E, et al., Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. Science. 2012 Jan 20;335(6066):344-8
• All: 1 reference(s)