Katnal1^1H
Chemically induced Allele Detail

Summary

• Symbol: Katnal1^1H
• Name: katanin p60 subunit A-like 1; ENU mutation 1, Harwell
• MGI ID: MGI:5309172
• Gene: Katnal1 Location: Chr5:148808394-148865978 bp, - strand Genetic Position: Chr5, 89.04 cM
• Alliance: Katnal1^1H page

Katnal1^1H/Katnal1^1H mice show disruption of the seminiferous epithelium associated with a reduction in numbers of post-meiotic germ cells

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Chemically induced (ENU) Mutation: Single point mutation Mutation details: A single point mutation (T to G) is located in exon 7. This point mtation results in a leucine to valine substitution at residue 286, within a conserved ATPase domain and creates a novel HpyAV restriction-enzyme recognition site. In vitro analysis indicates that this is a loss of function allele. In Sertoli cells from homozygous mice protein is restricted to the basal compartment rather than being throughout the basal and adluminal compartments. (J:185195) Inheritance: Recessive

Schematic of the Katnal1^1H allele

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Katnal1 Mutation: 24 strains or lines available

References

• Original: J:185195 Smith LB, et al., KATNAL1 Regulation of Sertoli Cell Microtubule Dynamics Is Essential for Spermiogenesis and Male Fertility. PLoS Genet. 2012 May;8(5):e1002697
• All: 2 reference(s)