Trap1a^tm1.1Jvde
Targeted Allele Detail

Summary

• Symbol: Trap1a^tm1.1Jvde
• Name: tumor rejection antigen P1A; targeted mutation 1.1, Benoit Van den Eynde
• MGI ID: MGI:5309174
• Synonyms: P1A^-
• Gene: Trap1a Location: ChrX:138234432-138238918 bp, + strand Genetic Position: ChrX, 61.35 cM
• Alliance: Trap1a^tm1.1Jvde page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180807
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of loxP sites, one into the Acc65I site located 15 bp upstream of the ATG in the first exon, and the other into the PstI site located in the first intron. Cre-mediated recombination removed exon 1. RT-PCR confirmed the absent of transcripts containing exon 1 in the testes and thymus. (J:180807)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trap1a Mutation: 8 strains or lines available

References

• Original: J:180807 Huijbers IJ, et al., Minimal tolerance to a tumor antigen encoded by a cancer-germline gene. J Immunol. 2012 Jan 1;188(1):111-21
• All: 1 reference(s)