Arl6^tm2Vcs
Targeted Allele Detail

Summary

• Symbol: Arl6^tm2Vcs
• Name: ADP-ribosylation factor-like 6; targeted mutation 2, Val C Sheffield
• MGI ID: MGI:5310744
• Synonyms: Bbs3^-
• Gene: Arl6 Location: Chr16:59433312-59459754 bp, - strand Genetic Position: Chr16, 34.83 cM, cytoband C1.2
• Alliance: Arl6^tm2Vcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180524
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6 and 7 were replaced with a neomycin selection cassette. RT-PCR and Western blot analysis confirmed that gene expression of both isoforms was disrupted. (J:180524)

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	26 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Arl6 Mutation: 24 strains or lines available

References

• Original: J:180524 Zhang Q, et al., Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20678-83
• All: 4 reference(s)