Gt(ROSA)26Sor^{tm3(Runx2)Flng}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(Runx2)Flng}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Fanxin Long
• MGI ID: MGI:5311032
• Synonyms: R26^Runx2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(Runx2)Flng} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180304
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm3(Runx2)Flng} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Runx2 (MGI:99829)

• Mutation details: The insertional construct contained a floxed neo/STOP cassette, the mouse Runx2 cDNA encoding the MASNS isoform, an IRES, EGFP and polyadenylation sequence. (J:180304)

Expression

In Mice Carrying this Mutation:

30 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:180304 Tu X, et al., Indian hedgehog requires additional effectors besides Runx2 to induce osteoblast differentiation. Dev Biol. 2012 Feb 1;362(1):76-82
• All: 2 reference(s)