b2b942Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b942Clo
• Name: Mutant line 942; Bench to Bassinet Program (B2B/CVDC), mutation 942 Cecilia Lo
• MGI ID: MGI:5311377
• Gene: b2b942Clo Location: unknown
• Alliance: b2b942Clo page

Pulmonary artery (PA) stenosis and malpositioning of the great arteries.

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. Additional incidental mutations were detected in sequencing for the causative mutation, b2b942Clo, and may be present in stocks carrying this mutation.

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b942Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:
Cardiovascular defects: Heterotaxy with congenital heart disease (CHD) such as double outlet right ventricle (DORV), atrio-ventricular septal defect (AVSD), common atrium, and pulmonary artery (PA) stenosis

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0600	Double outlet right ventricle
1622	Pulmonary artery stenosis
3804	Congenital heart disease
3817	Abdominal situs ambiguous (abdominal heterotaxy)

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)