Kdm8^tm1Tasu
Targeted Allele Detail

Summary

• Symbol: Kdm8^tm1Tasu
• Name: lysine (K)-specific demethylase 8; targeted mutation 1, Takeshi Suzuki
• MGI ID: MGI:5311829
• Synonyms: Jmjd5^neo
• Gene: Kdm8 Location: Chr7:125043848-125061441 bp, + strand Genetic Position: Chr7, 68.85 cM, cytoband F3
• Alliance: Kdm8^tm1Tasu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181189
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT flanked inverted neo cassette and second loxP site were inserted downstream of exon 4 via homologous recombination. RT-PCR indicates RNA expression is significantly reduced in homozygous mice. This is a hypomorphic allele. (J:181189)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm8 Mutation: 18 strains or lines available

References

• Original: J:181189 Ishimura A, et al., Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression. Development. 2012 Feb;139(4):749-59
• All: 3 reference(s)