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Ift140tm1b(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Ift140tm1b(KOMP)Wtsi
Name: intraflagellar transport 140; targeted mutation 1b, Wellcome Trust Sanger Institute
MGI ID: MGI:5311831
Synonyms: Ift140null1
Gene: Ift140  Location: Chr17:25235056-25318461 bp, + strand  Genetic Position: Chr17, 12.53 cM
Alliance: Ift140tm1b(KOMP)Wtsi page
IMPC: Ift140 gene page
Mutation
origin
Mutant Cell Lines:  EPD0073_5_F01, EPD0073_5_G01
Germline Transmission:  Earliest citation of germline transmission: J:181533
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 25168608 of Chromosome 17 upstream of the critical exon(s) (Build 37). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 7 at position 25169359. Exon 7 is thus flanked by loxP sites. Cre expression excised exon 7 and the neomycin selection cassette resulting in the creation of a reporter knockout mouse. (J:148605, J:173534, J:181533)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ift140 Mutation:  71 strains or lines available
References
Original:  J:181533 Jonassen JA, et al., Disruption of IFT complex A causes cystic kidneys without mitotic spindle misorientation. J Am Soc Nephrol. 2012 Apr;23(4):641-51
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory