Il5^tm1Ktk
Targeted Allele Detail

Summary

• Symbol: Il5^tm1Ktk
• Name: interleukin 5; targeted mutation 1, Kiyoshi Takatsu
• MGI ID: MGI:5312092
• Synonyms: Il5^tm1.1Ktk, IL5^V, IL5^Venus
• Gene: Il5 Location: Chr11:53611621-53615930 bp, + strand Genetic Position: Chr11, 31.99 cM, cytoband A5/B1
• Alliance: Il5^tm1Ktk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180790
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A Venus reporter and floxed neo cassette was inserted at the translation initiation site. Cre-mediated recombination removed the neo cassette. Flow cytometry confirmed the absence of protein expression in cultured Th2+ cells stimulated with PMA and ionomycin or anti-CD3 antibodies. (J:180790)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il5 Mutation: 31 strains or lines available

References

• Original: J:180790 Ikutani M, et al., Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity. J Immunol. 2012 Jan 15;188(2):703-13
• All: 12 reference(s)