Xpa^tm1Gvh
Targeted Allele Detail

Summary

• Symbol: Xpa^tm1Gvh
• Name: xeroderma pigmentosum, complementation group A; targeted mutation 1, Gijsbertus T J van der Horst
• MGI ID: MGI:5312129
• Synonyms: Xpa^c
• Gene: Xpa Location: Chr4:46175222-46196317 bp, - strand Genetic Position: Chr4, 24.49 cM, cytoband C2
• Alliance: Xpa^tm1Gvh page

Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs Tg(CAG-cre)13Miya/0 mice are severely reduced in size

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179808
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutations: Insertion, Intragenic deletion Mutation details: A construct replaced exon 4. This construct contains (5' to 3'): loxP, cDNA encoding exons 4-6, hygro, loxP, splice acceptor, Murfi cassette, IRES, lacZ and GFP. (J:179808)

Generation of the Xpa^tm1Gvh allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xpa Mutation: 21 strains or lines available

References

• Original: J:179808 Jaarsma D, et al., Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology. PLoS Genet. 2011 Dec;7(12):e1002405
• All: 2 reference(s)